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We demonstrate that one contributing mechanism is that ultra-low dose naltrexone blocks opioid-induced activation of spinal glial cells.

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REVIA is a pure opioid antagonistIt markedly attenuates or completely blocksreversiblythe subjective effects of intravenously administered opioids.

Data collected from postmarketing use of REVIA show that most events usually occur early in the course of drug therapy and are transientIt is not always possible to distinguish these occurrences from those signs and symptoms that may result from a withdrawal syndromeEvents that have been reported include anorexiaastheniachest painfatigueheadachehot flushesmalaisechanges in blood pressureagitationdizzinesshyperkinesianauseavomitingtremorabdominal paindiarrheapalpitationsmyalgiaanxietyconfusioneuphoriahallucinationsinsomnianervousnesssomnolenceabnormal thinkingdyspnearashincreased sweatingvision abnormalitiesand idiopathic thrombocytopenic purpura.

REVIA and its primary metabolite are excreted primarily in the urineand caution is recommended in administering the drug to patients with renal impairment.

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